This is a non exhaustive list of publications related to ELF work published in scientific journals. Please contact the programme office if you miss a relevant publication.
Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0
Hit discovery for public target programmes in the European Lead Factory: Experiences and output from assay development and ultra-High Throughput Screening
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.
Beck, E.M.; Parnell, E.; Cowley, A.; Porter, A.; Gillespie, J.; Robinson, J.; Robinson, L.; Pannifer, A.D.; Hamon, V.; Jones, P.; Morrison, A.; McElroy, S.; Timmerman, M.; Rutjes, H.; Mahajan, P.; Wiejak, J.; Luchowska-Stańska, U.; Morgan, D.; Barker, G.; Rehmann, H.; Yarwood, S.J.
Cells 2019, 8, 1425
doi: https://doi.org/10.3390/cells8111425 12 November 2019
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
Elena De Vita, Niels Smits, Helma van den Hurk, Elizabeth M. Beck ,Joanne Hewitt, Gemma Baillie, Emily Russell, Andrew Pannifer, Véronique Hamon, Angus Morrison, Stuart P. McElroy, Philip Jones, Natalia A. Ignatenko, Nikolas Gunkel, Aubry K. Miller.
ChemMedChem, Volume 15, Issue 1: 79-95
doi: https://doi.org/10.1002/cmdc.201900536 January 7, 2020
Diastereoselective Synthesis of Highly Substituted, Amino‐and Pyrrolidino‐Tetrahydrofurans as Lead‐Like Molecular Scaffolds
Steven M. Wales, Elena G. Merisor, Holly V. Adcock, Christopher A. Pearce, Ian R. Strutt, William Lewis, Daniel Hamza, Christopher J. Moody
Chemistry–A European Journal. 2018;24(32):8233-9.
doi: https://doi.org/10.1002/chem.201801046 2018 June 7
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory
Polycyclic Sulfoximines as New Scaffolds for Drug Discovery
Mark L. G. Borst, Cécile M. J. Ouairy, Sander C. Fokkema, Alessandro Cecchi, Jessica M. C. A. Kerckhoffs, Vincent L. de Boer, Peter J. van den Boogaard, Rutger F. Bus, Rijko Ebens, Rob van der Hulst, Joop Knol, Rob Libbers, Zhou M. Lion, Bart W. Settels, Ellen de Wever, Khaled A. Attia, Piet-Jan Sinnema, Jesse M. de Gooijer, Karen Harkema, Marieke Hazewinkel, Susan Snijder, Kees Pouwer
ACS Comb. Sci. 2018;20(6):335-343
doi: 10.1021/acscombsci.7b00150 2018 May 1
Petasis/Diels‐Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production
MicroScale Thermophoresis Sharpens Hit Triaging: European Lead Factory Combines HTS and a Biophysical Assay to Refine Early Drug Discovery
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